Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes, F-35000, France.
Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes, F-35000, France.
Environ Health. 2024 Oct 4;23(1):79. doi: 10.1186/s12940-024-01120-z.
Organic solvents are used in formulating an extensive range of products for professional use. Animal and human studies suggest that in utero solvent exposure may affect neurodevelopment. Our objective was to assess the association between occupational exposure to solvents during pregnancy and child behavior aged 2-12 years.
The French mother-child cohort PELAGIE (2002-2006) included 3,421 women recruited in early pregnancy. Occupational exposure to solvents was self-reported. For 459 children, parents used a questionnaire derived from the Child Behavior Checklist and the Preschool Social Behavior Questionnaire to assess their child's behavior, at age 2, and the Strengths and Difficulties Questionnaire at ages 6 and 12. A cross-lagged structural equation modeling approach was used to assess direct and indirect associations between exposure and child behavior.
At age 2, an increased externalizing behavior score was suggested with prenatal exposure to solvents (mean change in standardized score (95%CI): 0.28 (-0.01, 0.57) for occasional exposure and 0.23 (-0.05, 0.51) for regular exposure). At ages 6 and 12, distinct sex-specific patterns were observed: among boys, no association with externalizing behavior was observed, while among girls, an association was seen for both occasional and regular exposure (total effect at age 12: 0.45 (0.06,0.83) and 0.40 (0.03, 0.76), respectively). For both sexes, occasional exposure may be associated with internalizing behavior at ages 6 and 12 (total effect at age 6: 0.37 (0.06, 0.68) and at age 12: 0.27 (-0.08, 0.62)).
Occupational exposure to solvents during pregnancy may impact child behavior through either direct or cumulative effects during childhood; these associations may persist until early adolescence, especially among girls.
有机溶剂被广泛应用于各种专业用途的产品配方中。动物和人类研究表明，胎儿在子宫内接触溶剂可能会影响神经发育。我们的目的是评估孕妇在怀孕期间接触溶剂与 2-12 岁儿童行为之间的关系。
法国母婴队列 PELAGIE（2002-2006 年）纳入了 3421 名在孕早期招募的妇女。职业暴露于溶剂是自我报告的。对于 459 名儿童，父母使用了一个源自儿童行为检查表和学龄前社交行为问卷的问卷，以评估他们的孩子在 2 岁时的行为，以及在 6 岁和 12 岁时的优势和困难问卷。采用交叉滞后结构方程模型方法评估暴露与儿童行为之间的直接和间接关联。
在 2 岁时，产前接触溶剂与外化行为评分增加有关（标准化评分的平均变化（95%CI）：偶尔接触时为 0.28（-0.01，0.57），定期接触时为 0.23（-0.05，0.51））。在 6 岁和 12 岁时，观察到了不同的性别特异性模式：在男孩中，未观察到与外化行为有关，而在女孩中，偶尔接触和定期接触均有关联（12 岁时的总效应：0.45（0.06，0.83）和 0.40（0.03，0.76））。对于两种性别，偶尔接触可能与 6 岁和 12 岁时的内化行为有关（6 岁时的总效应：0.37（0.06，0.68）和 12 岁时的总效应：0.27（-0.08，0.62））。
孕妇在怀孕期间接触溶剂可能会通过儿童期的直接或累积效应影响儿童行为；这些关联可能会持续到青春期早期，尤其是在女孩中。
