Katz David L, Evans Marian A, Chan Wendy, Nawaz Haq, Comerford Beth Patton, Hoxley Martha L, Njike Valentine Yanchou, Sarrel Philip M
Yale Prevention Research Center, 130 Division Street, Derby, CT 06418, USA.
J Am Coll Nutr. 2004 Oct;23(5):397-403. doi: 10.1080/07315724.2004.10719384.
To determine effects of oat and antioxidant vitamin (C 500 mg, E 400 IU) ingestion on endothelial function in overweight, dyslipidemic adults.
Randomized, blinded, placebo-controlled, crossover trial Intervention(s): Subjects (16 males > or = age 35; 14 postmenopausal females) were assigned, in random order, to oats (60 g oatmeal), vitamin E (400 IU) plus vitamin C (500 mg), the combination of oats and vitamins, or placebo, and underwent brachial artery reactivity scans (BARS) following a single dose of each treatment, and again following 6 weeks of daily ingestion, with 2-week washout periods. At each test, a provocation high-fat meal (50 g, predominantly saturated) was administered and subjects were scanned pre, and 3 hours post-ingestion.
Mean flow-mediated vasodilation (FMD; measured as percent diameter change before and after treatments) at baseline was 6.35 +/- 3.37. Oats increased FMD non-significantly (p > 0.05) with both single acute dose (from 6.07 +/- 6.25 to 9.22 +/- 8.82) and six weeks of sustained treatment (from 6.01 +/- 10.07 to 8.69 +/- 8.42). The direction of effect was negative for vitamins and the oat/vitamin combination with both acute and sustained treatment. There were no significant differences in FMD change among the treatments in either phase of the study, however when acute and sustained effects were pooled, oat treatment significantly augmented FMD (p < 0.05).
This trial suggests but does not confirm a beneficial influence of oat ingestion on endothelial function in overweight, dyslipidemic adults. Further study of this potential association is warranted.
确定摄入燕麦和抗氧化维生素（维生素C 500毫克、维生素E 400国际单位）对超重、血脂异常成年人内皮功能的影响。
随机、双盲、安慰剂对照、交叉试验。干预措施：受试者（16名年龄≥35岁的男性；14名绝经后女性）被随机分配，依次接受燕麦（60克燕麦片）、维生素E（400国际单位）加维生素C（500毫克）、燕麦与维生素的组合或安慰剂治疗。在每次单剂量治疗后以及每日摄入6周后进行肱动脉反应性扫描（BARS），每次治疗之间有2周的洗脱期。每次测试时，给予一顿高脂激发餐（50克，主要为饱和脂肪），并在摄入前和摄入后3小时对受试者进行扫描。
基线时平均血流介导的血管舒张（FMD；以治疗前后直径变化百分比衡量）为6.35±3.37。单次急性剂量燕麦（从6.07±6.25增至9.22±8.82）和持续治疗6周（从6.01±10.07增至8.69±8.42）后，FMD虽有增加但无显著差异（p>0.05）。维生素以及燕麦/维生素组合在急性和持续治疗时FMD的变化趋势均为负。在研究的两个阶段中，各治疗组间FMD变化均无显著差异，然而，当合并急性和持续效应时，燕麦治疗可显著增加FMD（p<0.05）。
本试验表明但未证实摄入燕麦对超重、血脂异常成年人的内皮功能有有益影响。有必要对这种潜在关联进行进一步研究。
