Plantinga Yvonne, Ghiadoni Lorenzo, Magagna Armando, Giannarelli Chiara, Franzoni Ferdinando, Taddei Stefano, Salvetti Antonio
Department of Internal Medicine, University of Pisa, Pisa, Italy.
Am J Hypertens. 2007 Apr;20(4):392-7. doi: 10.1016/j.amjhyper.2006.09.021.
Essential hypertension is characterized by endothelial dysfunction, arterial stiffness, and increased oxidative stress. We evaluated the effect of short-term combined treatment with the antioxidants vitamins C and E on endothelial function, arterial stiffness, and oxidative stress in untreated essential hypertensive patients.
A randomized, double-blind, placebo-controlled, crossover study design was used to assign 30 male essential hypertensive patients to either vitamin C (1 g) and vitamin E (400 IU) or placebo for 8 weeks. Endothelium-dependent response was assessed as flow-mediated dilation (FMD) of the brachial artery. Arterial stiffness was assessed as central pulse wave velocity (PWV) and augmentation index (AIx). Plasma markers of oxidative stress and antioxidant status were measured.
After vitamin supplementation, FMD was significantly improved. Central PWV was significantly reduced, while AIx tended to decrease. Plasma vitamin levels and antioxidant capacity increased significantly. Levels of oxidative stress decreased. Changes in central PWV were related to changes in levels of oxidative stress.
Combined treatment with vitamins C and E has beneficial effects on endothelium-dependent vasodilation and arterial stiffness in untreated, essential hypertensive patients. This effect is associated with changes in plasma markers of oxidative stress.
原发性高血压的特征是内皮功能障碍、动脉僵硬度增加和氧化应激增强。我们评估了抗氧化剂维生素C和E短期联合治疗对未经治疗的原发性高血压患者内皮功能、动脉僵硬度和氧化应激的影响。
采用随机、双盲、安慰剂对照、交叉研究设计，将30名男性原发性高血压患者分为维生素C（1克）和维生素E（400国际单位）组或安慰剂组，治疗8周。内皮依赖性反应通过肱动脉的血流介导的血管舒张（FMD）进行评估。动脉僵硬度通过中心脉搏波速度（PWV）和增强指数（AIx）进行评估。测量氧化应激和抗氧化状态的血浆标志物。
补充维生素后，FMD显著改善。中心PWV显著降低，而AIx有下降趋势。血浆维生素水平和抗氧化能力显著增加。氧化应激水平降低。中心PWV的变化与氧化应激水平的变化有关。
维生素C和E联合治疗对未经治疗的原发性高血压患者的内皮依赖性血管舒张和动脉僵硬度有有益影响。这种作用与氧化应激血浆标志物的变化有关。
