临床医学中的基因治疗。
Gene therapy in clinical medicine.
作者信息
Selkirk S M
机构信息
Department of Neurology, University Hospital of Cleveland, Hanna House 5, 11100 Euclid Avenue, Cleveland, OH 44106, USA.
出版信息
Postgrad Med J. 2004 Oct;80(948):560-70. doi: 10.1136/pgmj.2003.017764.
Abstract
Although the field of gene therapy has experienced significant setbacks and limited success, it is one of the most promising and active research fields in medicine. Interest in this therapeutic modality is based on the potential for treatment and cure of some of the most malignant and devastating diseases affecting humans. Over the next decade, the relevance of gene therapy to medical practices will increase and it will become important for physicians to understand the basic principles and strategies that underlie the therapeutic intervention. This report reviews the history, basic strategies, tools, and several current clinical paradigms for application.
摘要
尽管基因治疗领域经历了重大挫折且取得的成功有限，但它仍是医学中最具前景且最活跃的研究领域之一。人们对这种治疗方式感兴趣是基于其治疗和治愈一些影响人类的最恶性、最具破坏性疾病的潜力。在未来十年，基因治疗与医疗实践的相关性将增加，医生了解治疗干预背后的基本原理和策略将变得很重要。本报告回顾了基因治疗的历史、基本策略、工具以及几种当前的临床应用范例。
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