Kim Hyo-Cheol, Lee Jeong Min, Choi Seung Hong, Han Heon, Kim Sam Soo, Lee Sang Hyun, Han Joon Koo, Choi Byung Ihn
Department of Radiology, Seoul National University College of Medicine, Institute of Radiation Medicine, SNUMRC, Chongno-gu, Korea.
Korean J Radiol. 2004 Jul-Sep;5(3):157-63. doi: 10.3348/kjr.2004.5.3.157.
This study was undertaken for the purpose of describing the CT features of intra-abdominal extra-hepatic metastases from gastrointestinal stromal tumors in patients who were treated with imatinib.
Eleven patients with intra-abdominal extra-hepatic metastases from gastrointestinal stromal tumors, who were treated with imatinib between May 2001 and December 2003, were included in this study. The clinical findings and CT scans were retrospectively reviewed. The metastatic lesions were assessed according to the location, size (greatest diameter), attenuation, and the enhancing pattern before and after imatinib treatment.
Prior to the treatment, the sizes and attenuation values of the metastatic lesions ranged from 5 to 20 cm and from 63 to 131 H, respectively. The metastatic lesions showed a heterogeneous enhancement pattern on the contrast-enhanced CT scans. After the treatment, the metastatic lesions became smaller in all 11 patients, and the corresponding attenuation value ranged from 15 to 51 H. The metastatic lesions became homogeneous and cystic in appearance on the follow-up CT scans, mimicking ascites.
Intra-abdominal extra-hepatic metastases of patients with gastrointestinal stromal tumors treated with imatinib may appear as well-circumscribed cystic lesions on contrast-enhanced CT. These metastases are likely to become smaller and resemble ascites, but may persist indefinitely on the followup CT.
本研究旨在描述接受伊马替尼治疗的胃肠道间质瘤患者腹腔内肝外转移灶的CT特征。
本研究纳入了2001年5月至2003年12月期间接受伊马替尼治疗的11例胃肠道间质瘤腹腔内肝外转移患者。对临床资料和CT扫描结果进行回顾性分析。根据转移灶的位置、大小（最大直径）、密度以及伊马替尼治疗前后的强化方式对转移灶进行评估。
治疗前，转移灶大小为5至20 cm，密度值为63至131 H。在增强CT扫描上，转移灶表现为不均匀强化。治疗后，11例患者的转移灶均变小，相应密度值为15至51 H。在随访CT扫描上，转移灶变得均匀且呈囊性，类似腹水。
接受伊马替尼治疗的胃肠道间质瘤患者腹腔内肝外转移灶在增强CT上可能表现为边界清晰的囊性病变。这些转移灶可能会变小并类似腹水，但在随访CT上可能会长期存在。
