Ras/Raf/ERK信号传导与神经纤维瘤病1型

Ras/Raf/ERK signalling and NF1.

作者信息

Harrisingh Marie C, Lloyd Alison C

机构信息

MRC Laboratory for Molecular Cell Biology and the Department of Biochemistry, University College London, Gower Street, London, UK.

出版信息

Cell Cycle. 2004 Oct;3(10):1255-8. doi: 10.4161/cc.3.10.1182. Epub 2004 Oct 17.

DOI:10.4161/cc.3.10.1182

PMID:15467460

Abstract

Ras signalling is important in the development of Schwann-cell-derived tumors in Neurofibromatosis Type 1 (NF1) patients. Schwann cells are a regenerative cell type, with no known stem-cell population. To produce new cells in the adult, for example following nerve damage, myelinating Schwann cells de-differentiate, proliferate and then re-differentiate during the repair process. We have found that Ras/Raf/ERK signalling can drive the de-differentiation of myelinated Schwann cells. In this review, we discuss how our results may contribute to the understanding of tumor formation in NF1 patients.

摘要

Ras信号传导在1型神经纤维瘤病（NF1）患者雪旺细胞源性肿瘤的发生发展中起着重要作用。雪旺细胞是一种再生细胞类型，目前尚无已知的干细胞群体。例如，在神经损伤后，为了在成体中产生新细胞，有髓雪旺细胞在修复过程中去分化、增殖，然后再分化。我们发现Ras/Raf/ERK信号传导可驱动有髓雪旺细胞的去分化。在本综述中，我们讨论了我们的研究结果如何有助于理解NF1患者的肿瘤形成。