反流性喉炎成人的唾液表皮生长因子浓度
Salivary epidermal growth factor concentration in adults with reflux laryngitis.
作者信息
Eckley Claudia A, Michelsohn Nelson, Rizzo Luiz Vicente, Tadokoro Carlos Eduardo, Costa Henrique O
机构信息
Otolaryngology Department, Santa Casa School of Medicine of São Paulo, Brasil.
出版信息
Otolaryngol Head Neck Surg. 2004 Oct;131(4):401-6. doi: 10.1016/j.otohns.2004.01.020.
OBJECTIVE
The mechanisms involved in the mucosal alterations of laryngopharyngeal reflux (LPR) have not been well established. Reports indicate a decrease in the salivary epidermal growth factor (EGF) of patients with reflux esophagitis, but there are no reports of its behavior in LPR. Our objective was to determine the salivary concentration of EGF in adults with LPR.
STUDY DESIGN AND SETTING
Salivary EGF concentration of 26 patients with LPR and 20 healthy controls was determined using a commercially available ELISA kit. Patients with LPR were graded according to endoscopic and laryngoscopic criteria.
RESULTS
Salivary EGF concentration was significantly lower in the LPR group when compared with controls (P = 0.002). No correlation between the severity of laryngeal findings or esophagitis and salivary EGF concentration could be determined.
CONCLUSIONS
The decreased salivary concentration of EGF in adults with LPR suggests that a deficiency in this polypeptide could be associated to the disease.
目的
喉咽反流（LPR）黏膜改变所涉及的机制尚未完全明确。报告显示反流性食管炎患者唾液表皮生长因子（EGF）水平降低，但尚无关于其在LPR中表现的报道。我们的目的是测定成年LPR患者唾液中EGF的浓度。
研究设计与设置
使用市售ELISA试剂盒测定26例LPR患者和20例健康对照者的唾液EGF浓度。LPR患者根据内镜和喉镜标准进行分级。
结果
与对照组相比，LPR组唾液EGF浓度显著降低（P = 0.002）。未发现喉部表现或食管炎的严重程度与唾液EGF浓度之间存在相关性。
结论
成年LPR患者唾液中EGF浓度降低表明该多肽缺乏可能与该病有关。
Zotero 插件