Burr D B
Department of Anatomy, Indiana University School of Medicine, Indianapolis 46202.
Anat Rec. 1992 Feb;232(2):180-9. doi: 10.1002/ar.1092320203.
Although macaques have been used widely to study the dynamics of bone remodeling, there have been few comparisons to skeletal tissue turnover in humans. This study analyzes variation in bone microstructure with respect to gender, age, and body weight in growing macaques to determine whether the pattern of osteonal remodelling in macaques is like that in analogous bones of humans. Histomorphometric measurements were made on femoral midshaft cross-sections of 54 macaques from the Cayo Santiago skeletal collection. These data show that variation in bone microstructure occurs independent of gender, age, and body weight in macaques. Moreover, intracortical bone turnover in the macaque femur is much slower than in humans, making them poor models to study the effects of weightlessness, but good models to study low turnover skeletal dysplasias.
尽管猕猴已被广泛用于研究骨重塑的动态过程，但与人类骨骼组织更新的比较却很少。本研究分析了生长中的猕猴骨微结构在性别、年龄和体重方面的差异，以确定猕猴骨单位重塑模式是否与人类类似骨骼中的模式相同。对来自圣地亚哥岛骨骼收藏的54只猕猴的股骨干中段横截面进行了组织形态计量学测量。这些数据表明，猕猴骨微结构的变化独立于性别、年龄和体重。此外，猕猴股骨的皮质内骨转换比人类慢得多，这使得它们成为研究失重影响的不良模型，但却是研究低转换型骨骼发育异常的良好模型。
