Hsu Shan-Hui, Kao Yu-Chih, Lin Zu-Chang
Department of Chemical Engineering, National Chung Hsing University, Taichung, 402, Taiwan.
Macromol Biosci. 2004 Apr 19;4(4):464-70. doi: 10.1002/mabi.200300082.
In this work, we synthesized two MDI-based polyurethanes, including a poly(ether)urethane (PEU) and a poly(carbonate)urethane (PCU), by using different soft segments, poly(tetramethylene oxide) and poly(hexyl, ethyl)carbonate diol (M approximately 2,000). We demonstrated that, in addition to the enhanced biostability of PCU over PEU, the biological performances of PCU in vitro were also improved in general. These included, better cellular attachment and proliferation, less platelet activation, as well as reduced monocyte activation. The unusual wide-ranging enhancement in biocompatibility for PCU was believed to be related to the larger micro-phase separation in PCU (approximately 25 nm) that caused distinct protein adsorption on the surface. The total number of adherent monocytes (nonactivated and activated) on the bare sample surfaces, albumin pre-adsorbed sample surfaces, and fibrinogen pre-adsorbed sample surfaces.
在这项工作中，我们通过使用不同的软段，聚四氢呋喃和聚（己基，乙基）碳酸酯二醇（M约为2000），合成了两种基于MDI的聚氨酯，包括聚（醚）聚氨酯（PEU）和聚（碳酸酯）聚氨酯（PCU）。我们证明，除了PCU比PEU具有更高的生物稳定性外，PCU的体外生物学性能总体上也得到了改善。这些包括更好的细胞附着和增殖、更少的血小板活化以及减少的单核细胞活化。PCU生物相容性的异常广泛增强被认为与PCU中较大的微相分离（约25nm）有关，这种微相分离导致表面上不同的蛋白质吸附。裸样品表面、白蛋白预吸附样品表面和纤维蛋白原预吸附样品表面上粘附的单核细胞（未活化和活化）总数。
