Hsu Shan-Hui, Kao Yu-Chih
Department of Chemical Engineering, National Chung Hsing University, Taichung, Taiwan ROC.
Macromol Biosci. 2005 Mar 15;5(3):246-53. doi: 10.1002/mabi.200400163.
Nanophase separation has been suggested to influence the biological performance of polyurethane. In a previous work, six different 4,4'-diphenylmethane diisocyanate (MDI)-based poly(carbonate urethane)s (PCUs) that exhibited various degrees of nanophase separation were synthesized and characterized. In the present work, these PCUs were used as a model system to study the effect of nanometric structures on the biocompatibility of polyurethane. Human blood platelet activation, monocyte activation, protein adsorption, and bacterial adhesion on PCU were investigated in vitro. It was found that human blood platelets as well as monocytes were less activated on the PCU surfaces with a greater degree of nanophase separation in general. This phenomenon was closely associated with the lower ratio of human fibrinogen/albumin competitively adsorbed on these surfaces. Bacterial adhesion was also inhibited in some nanophase-separated PCUs. [diagram in text].
有人提出纳米相分离会影响聚氨酯的生物学性能。在之前的一项工作中，合成并表征了六种不同的基于4,4'-二苯基甲烷二异氰酸酯（MDI）的聚（碳酸酯聚氨酯）（PCU），它们表现出不同程度的纳米相分离。在本工作中，这些PCU被用作模型系统来研究纳米结构对聚氨酯生物相容性的影响。体外研究了PCU上的人血小板活化、单核细胞活化、蛋白质吸附和细菌粘附。结果发现，一般来说，在具有更大程度纳米相分离的PCU表面上，人血小板和单核细胞的活化程度较低。这种现象与竞争性吸附在这些表面上的人纤维蛋白原/白蛋白的较低比例密切相关。在一些纳米相分离的PCU中，细菌粘附也受到抑制。[文中的图表]
