Verbsky James W, White Andrew J
Division of Rheumatology, Department of Pediatrics, Washington University School of Medicine, St. Lousis Children's Hospital, Missouri 63110, USA.
J Rheumatol. 2004 Oct;31(10):2071-5.
Systemic onset juvenile rheumatoid arthritis (SOJRA) is a multisystem disease characterized by high fever, rash, arthritis, serositis, splenomegaly, and laboratory evidence of systemic inflammation. Anticytokine therapies show promise in the treatment of chronic arthritides in children. We describe the use of the recombinant interleukin 1 receptor antagonist anakinra in 2 patients with therapy resistant SOJRA. Both patients experienced immediate and sustained resolution of symptoms and laboratory markers of inflammation, in one case after years of treatment with other immunosuppressive therapies.
全身型幼年类风湿性关节炎（SOJRA）是一种多系统疾病，其特征为高热、皮疹、关节炎、浆膜炎、脾肿大以及全身炎症的实验室证据。抗细胞因子疗法在治疗儿童慢性关节炎方面显示出前景。我们描述了重组白细胞介素1受体拮抗剂阿那白滞素在2例对治疗耐药的SOJRA患者中的应用。两名患者的症状和炎症实验室指标均立即且持续缓解，其中1例是在接受其他免疫抑制疗法治疗多年后出现这种情况。
