Harrison L H, Schechter M
Department of Epidemiology, University of Pittsburgh Graduate School of Public Health and School of Medicine, Pittsburgh, Pennsylvania 15261, USA.
AIDS Patient Care STDS. 1998 Aug;12(8):619-23. doi: 10.1089/apc.1998.12.619.
Human T-lymphotropic virus type I (HTLV-I) and HTLV-II have been postulated to accelerate disease progression in patients coinfected with HIV. However, recent evidence suggests that HTLV-II has no effect on HIV disease progression. In addition, it has recently been reported that HIV viral load was not increased in subjects coinfected with HTLV-I, suggesting that the biologic basis for the hypothesis does not exist. Several recent studies in Brazil, however, suggest that coinfection with HTLV-I and HIV has substantial medical consequences. For example, coinfection was associated with a higher CD4 lymphocytes count following adjustment for HIV viral load or HIV clinical stage. In addition, coinfected subjects have a high prevalence of clinical significant myelopathy. The effect of other putative viruses as cofactors in HIV disease progression is also discussed.
I型人类嗜T淋巴细胞病毒（HTLV-I）和HTLV-II被认为会加速合并感染HIV患者的疾病进展。然而，最近的证据表明，HTLV-II对HIV疾病进展没有影响。此外，最近有报道称，合并感染HTLV-I的受试者中HIV病毒载量并未增加，这表明该假设的生物学基础并不存在。然而，巴西最近的几项研究表明，HTLV-I与HIV合并感染会产生重大医学后果。例如，在对HIV病毒载量或HIV临床分期进行调整后，合并感染与较高的CD4淋巴细胞计数相关。此外，合并感染的受试者中具有临床意义的脊髓病患病率很高。本文还讨论了其他假定病毒作为HIV疾病进展辅助因子的作用。
