Shoda Hirofumi, Oka Teruaki, Inoue Morihiro, Kusaka Seishi, Tsuneyoshi Hideo, Miyazaki Jun, Sunaga Shinji
Department of Internal Medicine, Odaira-Memorial Tokyo Hitachi Hospital, 3-5-7 Yushima, Bunkyo-ku, Tokyo 113-0034.
Intern Med. 2004 Aug;43(8):741-5. doi: 10.2169/internalmedicine.43.741.
Sinus histiocytosis with massive lymphadenopathy (SHML) is a distinct benign clinicopathological entity, characterized by painless enlargement of lymph nodes due to sinus histiocytosis. Here, we report a case of SHML with diffuse large B-cell lymphoma. A 64-year-old man was admitted to our hospital because of fever. He presented with enlargement of a small cervical lymph node and huge abdominal paraaortic lymphadenopathy. Cervical lymph node biopsy revealed SHML and bone marrow biopsy showed infiltration of large B-cell lymphoma. Several cases of SHML associated with lymphoma have been documented to date, but this type of simultaneous occurrence has not yet been reported.
伴巨大淋巴结病的窦性组织细胞增生症（SHML）是一种独特的良性临床病理实体，其特征是由于窦性组织细胞增生导致淋巴结无痛性肿大。在此，我们报告一例合并弥漫性大B细胞淋巴瘤的SHML病例。一名64岁男性因发热入住我院。他表现为颈部一个小淋巴结肿大及巨大的腹主动脉旁淋巴结病。颈部淋巴结活检显示为SHML，骨髓活检显示有大B细胞淋巴瘤浸润。迄今为止，已有数例SHML与淋巴瘤相关的病例报道，但这种同时发生的情况尚未见报道。
