Lu D, Estalilla O C, Manning J T, Medeiros L J
Division of Pathology, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
Mod Pathol. 2000 Apr;13(4):414-9. doi: 10.1038/modpathol.3880071.
Sinus histiocytosis with massive lymphadenopathy (SHML), also known as Rosai-Dorfman disease, is a disorder of unknown cause. Rarely, patients with SHML also have malignant lymphoma, usually involving anatomic sites different from those involved by SHML We report four patients in whom SHML and malignant lymphoma were identified in the same lymph node biopsy specimen. The SHML in each case was present as a small focus, less than 1 cm. Immunohistochemical studies showed that the abnormal histiocytes were positive for S-100 and negative for CD1a. The malignant lymphomas included two cases of follicular lymphoma and two cases of Hodgkin's disease, nodular lymphocyte predominant type. The presence of SHML in these patients did not impact clinical decisions, and there was no evidence of SHML elsewhere. Thus, the presence of focal SHML associated with malignant lymphoma in these cases was an incidental histologic finding that seems not to have had any clinical significance.
伴巨大淋巴结病的窦组织细胞增生症（SHML），也称为罗萨伊-多夫曼病，是一种病因不明的疾病。SHML患者很少同时患有恶性淋巴瘤，通常涉及与SHML不同的解剖部位。我们报告了4例在同一淋巴结活检标本中同时发现SHML和恶性淋巴瘤的患者。每例中的SHML均表现为小于1 cm的小病灶。免疫组织化学研究显示，异常组织细胞S-100呈阳性，CD1a呈阴性。恶性淋巴瘤包括2例滤泡性淋巴瘤和2例结节性淋巴细胞为主型霍奇金病。这些患者中SHML的存在并未影响临床决策，且其他部位未发现SHML证据。因此，这些病例中与恶性淋巴瘤相关的局灶性SHML是一个偶然的组织学发现，似乎没有任何临床意义。
