Lee Myongsoo, Lee Sun-Ja, Jiang Li-Hong
Center for Supramolecular Nano-Assembly and Department of Chemistry, Yonsei University, Seoul 120-749, Korea.
J Am Chem Soc. 2004 Oct 13;126(40):12724-5. doi: 10.1021/ja045918v.
We synthesized tetrameric amphiphilic molecules based on a calixarene building block that self-assembles into a tunable and stable aggregation structure in aqueous solution. The amphiphilic calixarene molecules with a small hydrophilic part were observed to assemble into a vesicular structure that decreases significantly in diameter with only small increases in the hydrophilic chain length. Further increasing the chain length induced the collapse of the vesicles into spherical micelles. Remarkably, the vesicles were also observed to transform into small globular micelles at lower pH, which can be used to trigger the release of the encapsulated hydrophilic guest molecules.
我们基于杯芳烃构建模块合成了四聚体两亲分子，该分子在水溶液中自组装成可调节且稳定的聚集结构。观察到具有小亲水部分的两亲性杯芳烃分子组装成囊泡结构，随着亲水链长度仅小幅增加，其直径显著减小。进一步增加链长会导致囊泡塌陷成球形胶束。值得注意的是，在较低pH值下也观察到囊泡转变为小的球状胶束，这可用于触发封装的亲水客体分子的释放。
