利图灵三环螺缩醛的立体选择性合成。
Stereoselective synthesis of the lituarine tricyclic spiroacetal.
作者信息
Robertson Jeremy, Meo Paul, Dallimore Jonathan W P, Doyle Bryan M, Hoarau Christophe
机构信息
Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.
出版信息
Org Lett. 2004 Oct 14;6(21):3861-3. doi: 10.1021/ol0483955.
PMID:15469368
Abstract
[reaction: see text] Oxidative cyclizations of 2-(4-hydroxybutyl)furan derivatives provide spirobutenolide acetals directly; on the basis of this methodology, we describe an asymmetric synthesis of a tricyclic spirobutenolide precursor to the C(7-18) fragment common to lituarines A-C.
摘要
[反应：见正文] 2-(4-羟丁基)呋喃衍生物的氧化环化反应可直接生成螺丁烯内酯缩醛；基于此方法，我们描述了一种对三环螺丁烯内酯前体的不对称合成，该前体是海石花碱A-C共有的C(7-18)片段。
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