关于螺旋星衫藻素a的合成：构建包含DEF-双螺缩醛的四环C26-C40亚基。
Toward the synthesis of spirastrellolide a: construction of a tetracyclic C26-C40 subunit containing the DEF-bis-spiroacetal.
作者信息
Paterson Ian, Anderson Edward A, Dalby Stephen M, Loiseleur Olivier
机构信息
University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
出版信息
Org Lett. 2005 Sep 15;7(19):4121-4. doi: 10.1021/ol051403c.
PMID:16146367
Abstract
[reaction: see text] A stereo-controlled synthesis of the fully elaborated C26-C40 tricyclic [5,6,6]-bis-spiroacetal of spirastrellolide A containing the C28 chlorine substituent is reported, exploiting asymmetric Sharpless dihydroxylation and boron-mediated allylation methodology.
摘要
[反应：见正文] 报道了一种利用不对称夏普莱斯双羟基化反应和硼介导的烯丙基化方法，对含有C28氯取代基的螺旋星孢菌素A的完全合成的C26 - C40三环[5,6,6] - 双螺缩醛进行立体控制合成。
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