Devincenzo John P
Department of Pediatrics, University of Tennessee, LeBonheur Children's Medical Center, Memphis, TN 38103, USA.
Pediatr Res. 2004 Dec;56(6):914-7. doi: 10.1203/01.PDR.0000145255.86117.6A. Epub 2004 Oct 6.
Heterogeneity in respiratory syncytial virus (RSV) disease severity likely is due to a combination of host and viral factors. Infection with RSV subgroup A is thought to produce more severe disease than RSV-B. Higher RSV loads correlate with greater disease severity in hospitalized infants. Whether subgroup-specific variations in disease severity result from differences in RSV load has not been studied. A total of 102 RSV-hospitalized infants <2 y of age were studied. Nasal washes were collected in a standardized manner and were cultured in <3 h in parallel with an RSV quantitative standard in a HEp-2 plaque assay. RSV-A (72%) was more frequent than RSV-B. Disease severity risk factors were similar between subgroups. RSV loads were similar between A and B subgroups (4.77 versus 4.68 log PFU/mL). Measures of disease severity were also similar between subgroups.
呼吸道合胞病毒（RSV）疾病严重程度的异质性可能是宿主和病毒因素共同作用的结果。据认为，与RSV-B相比，感染RSV A亚组会导致更严重的疾病。在住院婴儿中，较高的RSV载量与更严重的疾病相关。疾病严重程度的亚组特异性差异是否由RSV载量差异导致尚未得到研究。对总共102名2岁以下因RSV住院的婴儿进行了研究。以标准化方式收集鼻洗液，并在<3小时内与RSV定量标准品平行在HEp-2空斑试验中培养。RSV-A（72%）比RSV-B更常见。亚组之间的疾病严重程度风险因素相似。A亚组和B亚组之间的RSV载量相似（4.77对4.68 log PFU/mL）。亚组之间的疾病严重程度指标也相似。
