Papademetriou Vasilios
Department of Cardiology, Georgetown University, Washington, DC, USA.
J Clin Hypertens (Greenwich). 2004 Oct;6(10 Suppl 2):14-7. doi: 10.1111/j.1524-6175.2004.03919.x.
The prevalence of heart failure is increasing in modern societies. Hypertension is a major contributor to the development of heart failure, whether through the development of left ventricular hypertrophy and diastolic dysfunction or by promoting atherosclerosis and myocardial infarction, which eventually leads to systolic dysfunction and left ventricular dysfunction. Effective therapy for hypertension can prevent more than 50% of heart failure events. Most studies done in the last three decades have used b blockers with diuretics as the modality of therapy. These agents have been shown to effectively prevent the development of heart failure. More recent comparative studies have shown that use of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers are also effective in preventing heart failure. Calcium channel blockers, however, seem to be less effective in preventing development of heart failure in patients with hypertension. It needs to be emphasized that the most important variable in preventing heart failure is the appropriate treatment of hypertension.
在现代社会中，心力衰竭的患病率正在上升。高血压是导致心力衰竭的主要因素，无论是通过左心室肥厚和舒张功能障碍的发展，还是通过促进动脉粥样硬化和心肌梗死，最终导致收缩功能障碍和左心室功能障碍。有效的高血压治疗可以预防超过50%的心力衰竭事件。过去三十年中进行的大多数研究都使用β受体阻滞剂和利尿剂作为治疗方式。这些药物已被证明能有效预防心力衰竭的发生。最近的比较研究表明，使用血管紧张素转换酶抑制剂和血管紧张素受体阻滞剂在预防心力衰竭方面也有效。然而，钙通道阻滞剂在预防高血压患者心力衰竭的发生方面似乎效果较差。需要强调的是，预防心力衰竭最重要的变量是对高血压进行恰当治疗。
