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老年人高血压的现行管理。

Current Management of Hypertension in Older Adults.

机构信息

Medical School, European University Cyprus, 76 Siggrou avenue, 11742, Athens, Greece.

Department of Internal Medicine, KAT General Hospital of Athens, Athens, Greece.

出版信息

Drugs Aging. 2023 May;40(5):407-416. doi: 10.1007/s40266-023-01013-9. Epub 2023 Mar 18.

DOI:10.1007/s40266-023-01013-9
PMID:36933178
Abstract

Hypertension is a major global health issue and it accounts for a big proportion of disability and mortality worldwide even in adults aged 65 years and above. Moreover, advanced age per se is an independent risk factor for adverse cardiovascular events and there is abundant scientific evidence supporting the beneficial effects of blood pressure lowering, within certain limits, in this subset of hypertensive patients. The aim of this review article is to summarize the available evidence regarding the appropriate management of hypertension in this specific subgroup, in an era of a constantly increasing aging population.

摘要

高血压是一个全球性的主要健康问题,它在全世界范围内导致了大量的残疾和死亡,即使是在 65 岁及以上的成年人中也是如此。此外,高龄本身就是不良心血管事件的一个独立危险因素,并且有大量的科学证据支持在这部分高血压患者中,在一定范围内降压的有益作用。本文的目的是总结在人口老龄化不断增加的时代,针对这一特定亚组人群,高血压的适当管理的现有证据。

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本文引用的文献

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Cardiovascular outcomes in adults with hypertension with evening versus morning dosing of usual antihypertensives in the UK (TIME study): a prospective, randomised, open-label, blinded-endpoint clinical trial.英国成人高血压患者中常规降压药物晚间与晨间给药的心血管结局(TIME 研究):一项前瞻性、随机、开放标签、盲终点临床试验。
Lancet. 2022 Oct 22;400(10361):1417-1425. doi: 10.1016/S0140-6736(22)01786-X. Epub 2022 Oct 11.
2
Role of ambulatory blood pressure monitoring in elderly hypertensive patients.动态血压监测在老年高血压患者中的作用。
Clin Hypertens. 2022 Jul 1;28(1):22. doi: 10.1186/s40885-022-00205-6.
3
Effect of acetaminophen on blood pressure: a systematic review and meta-analysis of randomized controlled trials.
对乙酰氨基酚对血压的影响:随机对照试验的系统评价和荟萃分析
Eur J Prev Cardiol. 2022 Oct 20;29(14):e326-e330. doi: 10.1093/eurjpc/zwac112.
4
SGLT2 inhibitors in hypertension: Role beyond diabetes and heart failure.高血压中的钠-葡萄糖协同转运蛋白2抑制剂:超越糖尿病和心力衰竭的作用。
Trends Cardiovasc Med. 2023 Nov;33(8):479-486. doi: 10.1016/j.tcm.2022.05.005. Epub 2022 May 18.
5
Effect of SGLT-2 inhibitor, empagliflozin, on blood pressure reduction in Chinese elderly hypertension patients with type 2 diabetes and its possible mechanisms.恩格列净对中国老年 2 型糖尿病高血压患者血压降低的作用及其可能机制。
Sci Rep. 2022 Mar 3;12(1):3525. doi: 10.1038/s41598-022-07395-x.
6
Regular Acetaminophen Use and Blood Pressure in People With Hypertension: The PATH-BP Trial.常服对乙酰氨基酚与高血压人群的血压:PATH-BP 试验。
Circulation. 2022 Feb 8;145(6):416-423. doi: 10.1161/CIRCULATIONAHA.121.056015. Epub 2022 Feb 7.
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Impact of bedtime dosing of antihypertensives compared to morning therapy: A meta-analysis of randomised controlled trials.与早晨用药相比,睡前服用抗高血压药物的影响:一项随机对照试验的荟萃分析。
Eur J Prev Cardiol. 2021 Sep 20;28(11):e5-e8. doi: 10.1177/2047487320903611. Epub 2020 Feb 3.
8
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Am J Prev Cardiol. 2020 May 1;1:100001. doi: 10.1016/j.ajpc.2020.100001. eCollection 2020 Mar.
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Hypertension. 2021 Aug;78(2):e26-e37. doi: 10.1161/HYP.0000000000000196. Epub 2021 Jun 2.
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