Allen J, Svane D, Petersen L K, Christensen J H, Forman A
Department of Obstetrics and Gynecology, Aarhus Kommunehospital, Denmark.
Br J Anaesth. 1992 Mar;68(3):256-60. doi: 10.1093/bja/68.3.256.
We have investigated the effects of thiopentone and chlormethiazole on maternal intramyometrial arteries dissected from myometrial biopsies taken during Caesarean section at term. Ring preparations were mounted in organ baths and isometric tension was recorded. Thiopentone 10(-4)-10(-3) mol litre-1 inhibited responses to K+ depolarization, noradrenaline and vasopressin. Chlormethiazole 3 x 10(-5)-3 x 10(-3) mol litre-1 inhibited responses to noradrenaline, while a concentration of 3 x 10(-3) mol litre-1 was required to attenuate responses to vasopressin and K+ depolarization. Neither of the two agents affected relaxant responses to prostacyclin. The results did not yield evidence that clinical use of thiopentone and chlormethiazole should impair uteroplacental vascular perfusion by a direct effect.
我们研究了硫喷妥钠和氯美噻唑对足月剖宫产时取自子宫肌层活检的母体子宫肌层内动脉的影响。将环状标本安装在器官浴槽中并记录等长张力。10⁻⁴ - 10⁻³摩尔/升的硫喷妥钠抑制对钾离子去极化、去甲肾上腺素和血管加压素的反应。3×10⁻⁵ - 3×10⁻³摩尔/升的氯美噻唑抑制对去甲肾上腺素的反应，而需要3×10⁻³摩尔/升的浓度来减弱对血管加压素和钾离子去极化的反应。这两种药物均不影响对前列环素的舒张反应。结果没有提供证据表明硫喷妥钠和氯美噻唑的临床应用会通过直接作用损害子宫胎盘血管灌注。
