Ashworth J R, Warren A Y, Baker P N, Johnson I R
Department of Obstetrics and Gynaecology, Nottingham City Hospital, UK.
Br J Obstet Gynaecol. 1997 Oct;104(10):1152-8. doi: 10.1111/j.1471-0528.1997.tb10939.x.
To measure endothelium-dependent relaxation in myometrial resistance arteries and to compare this parameter in nonpregnant and normotensive pregnant women and those with pregnancies complicated by pre-eclampsia.
A prospective study.
Nottingham City Hospital.
Thirty-seven nonpregnant women undergoing hysterectomy and 51 pregnant women undergoing caesarean section, of whom there were 39 normotensive and 12 with pre-eclampsia.
Resistance arteries, dissected from myometrial biopsies, were mounted on a wire myograph and preconstricted with vasopressin then subjected to incremental doses of bradykinin.
Endothelium-dependent relaxation to bradykinin was seen in the vessels of nonpregnant and normotensive pregnant women. Markedly reduced endothelium-dependent relaxation was found in the myometrial arteries from women with pre-eclampsia when compared with both nonpregnant (P < 0.0001) and normotensive pregnant (P < 0.0001) women.
A significant loss of endothelium-dependent relaxation in myometrial resistance arteries in pre-eclampsia may contribute to the altered vasoreactivity seen in pre-eclampsia, and particularly to the decreased placental perfusion and fetal growth retardation commonly associated with this condition.
测量子宫肌层阻力动脉的内皮依赖性舒张功能，并比较非妊娠、血压正常的孕妇以及合并子痫前期孕妇的这一参数。
一项前瞻性研究。
诺丁汉市医院。
37例行子宫切除术的非妊娠女性和51例行剖宫产术的孕妇，其中39例血压正常，12例合并子痫前期。
从子宫肌层活检中分离出阻力动脉，安装在钢丝肌动描记器上，先用血管加压素预收缩，然后给予递增剂量的缓激肽。
非妊娠和血压正常的孕妇血管中可见对缓激肽的内皮依赖性舒张。与非妊娠女性（P<0.0001）和血压正常的孕妇（P<0.0001）相比，子痫前期女性子宫肌层动脉的内皮依赖性舒张明显降低。
子痫前期子宫肌层阻力动脉内皮依赖性舒张功能显著丧失，可能导致子痫前期所见的血管反应性改变，尤其是导致与该疾病常见相关的胎盘灌注减少和胎儿生长受限。
