神经外科患者对皮下注射肾上腺素的心血管反应减弱。

Attenuation of the cardiovascular responses to subcutaneous adrenaline in neurosurgical patients.

作者信息

Muralidhar K, Bhanumurthy S

机构信息

Department of Anaesthesia, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad, India.

出版信息

Br J Anaesth. 1992 Mar;68(3):264-7. doi: 10.1093/bja/68.3.264.

DOI:10.1093/bja/68.3.264

PMID:1547049

Abstract

In 30 neurosurgical patients after induction of anaesthesia and random pretreatment with i.v. propranolol 1 mg or metoprolol 1 mg, heart rate and mean arterial pressure were measured at 30-s intervals after subcutaneous infiltration of adrenaline 1:200,000. While metoprolol prevented the cardiovascular effects of adrenaline infiltration, propranolol pretreatment was associated with a highly significant increase (P less than 0.01) in mean arterial pressure and a significant decrease (P less than 0.05) in heart rate. These results confirm the potentially serious interaction of propranolol and adrenaline during anaesthesia, and support the use of metoprolol instead, to obtund the cardiovascular effects of adrenaline infiltration.

摘要

在30例神经外科手术患者中，麻醉诱导后随机静脉注射1mg普萘洛尔或1mg美托洛尔进行预处理，皮下浸润1:200,000肾上腺素后，每隔30秒测量心率和平均动脉压。美托洛尔可预防肾上腺素浸润的心血管效应，而普萘洛尔预处理则导致平均动脉压显著升高（P<0.01），心率显著降低（P<0.05）。这些结果证实了麻醉期间普萘洛尔与肾上腺素之间可能存在严重相互作用，并支持使用美托洛尔来减轻肾上腺素浸润的心血管效应。