Jakobsen C J, Blom L
Department of Anaesthesia, Holstebro Central Hospital, Denmark.
Eur J Anaesthesiol. 1992 May;9(3):209-15.
The effect of a pre-operative dose of metoprolol on the catecholamine and cardiovascular responses to tracheal intubation and surgery, cardiac complications and intra-operative blood loss, were studied in patients undergoing elective hysterectomy during general anaesthesia. The study was double-blind and placebo controlled. The patients received metoprolol 100 mg or placebo orally 1-25 h before anaesthesia. In patients given metoprolol, heart rate and mean arterial pressure were lower during the first 45 min of anaesthesia. Plasma adrenaline and noradrenaline concentrations increased in both groups in response to tracheal intubation and surgery, but were higher after metoprolol. The incidence of arrhythmias was less after metoprolol. The mean operative blood loss was greater in the placebo group (486 +/- 170 ml (SEM) compared to 231 +/- 43 ml (SEM) after metoprolol). We conclude that oral premedication with metoprolol attenuates the hypertensive response to tracheal intubation and reduces both arrhythmias and operative blood loss.
在全身麻醉下行择期子宫切除术的患者中，研究了术前一剂美托洛尔对儿茶酚胺、气管插管及手术引起的心血管反应、心脏并发症和术中失血量的影响。该研究为双盲、安慰剂对照试验。患者在麻醉前1 - 25小时口服100毫克美托洛尔或安慰剂。给予美托洛尔的患者在麻醉的前45分钟内心率和平均动脉压较低。两组患者的血浆肾上腺素和去甲肾上腺素浓度在气管插管及手术过程中均升高，但美托洛尔组升高幅度更大。美托洛尔组心律失常的发生率较低。安慰剂组的平均术中失血量更大（486±170毫升（标准误），而美托洛尔组为231±43毫升（标准误））。我们得出结论，术前口服美托洛尔可减轻气管插管引起的高血压反应，并减少心律失常和术中失血量。
