Scott David E, Bergevin Michael
Department of Pathology and Anatomy, Eastern Virginia Medical School, Norfolk, VA 23507, USA.
Anat Rec A Discov Mol Cell Evol Biol. 2005 Jan;282(1):8-12. doi: 10.1002/ar.a.20104.
The germinal matrix neuroepithelium and the choroidal fissure of the fetal choroid plexus commonly possess microvessels that are often poorly developed. There may be a reduction of type IV collagen that surrounds these fragile microvessels. During the first and second trimester of neural development, these microvessels are friable and can undergo intraventricular hemorrhage under a number of circumstances. Early subtle changes in the integrity of germinal matrix epithelium are not easily visualized by ultrasound. The current investigation employing scanning electron microscopy clearly defines subtle hemorrhagic events and tearing of the germinal matrix neuroepithelium in the brains of human fetuses. A 23-week-old fetus survived for 11 days but died from other causes. The choroid plexus of this fetus was compared with the choroid plexus and germinal matrix epithelium of a 22-week-old fetus that was the product of an elective termination due to severe anhydramnios of unknown origin and a 19-week-old male fetus from an elective termination. All tissues were autopsy material not requiring institutional review board approval.
胎儿脉络丛的生发基质神经上皮和脉络膜裂隙通常有发育不良的微血管。围绕这些脆弱微血管的IV型胶原蛋白可能会减少。在神经发育的头三个月，这些微血管很脆弱，在多种情况下可发生脑室内出血。超声不易观察到生发基质上皮完整性的早期细微变化。目前采用扫描电子显微镜的研究清楚地界定了人类胎儿大脑中生发基质神经上皮的细微出血事件和撕裂情况。一名23周大的胎儿存活了11天，但死于其他原因。将该胎儿的脉络丛与一名22周大胎儿的脉络丛和生发基质上皮进行比较，后者因不明原因的严重羊水过少而被选择性终止妊娠，还有一名19周大的男性胎儿也被选择性终止妊娠。所有组织均为尸检材料，无需机构审查委员会批准。
