Lenn N J, Whitmore L
Pediatr Res. 1985 Jan;19(1):130-5. doi: 10.1203/00006450-198501000-00034.
To explain the reported predisposition to germinal matrix hemorrhage in premature infants, pathogenetically important morphological features of the germinal matrix should be present in the 3rd trimester and rapidly change near term. Such features were sought in this study of the germinal matrix and its vasculature in normal rhesus monkey fetuses. The matrix cells, glia, ependyma, and capillaries showed no important structural changes during the 3rd trimester. The terminal vein tributaries were greatly enlarged by 148 days, but cellular and collagen support in their walls was minimal at this time. The latter features developed by the final days of gestation. These findings do not support a structural immaturity or specialization of the germinal matrix predisposing to germinal matrix hemorrhage. Our results, therefore, support the recent emphasis on physiological parameters in the pathogenesis and prevention of germinal matrix hemorrhage.
为了解释早产儿生发基质出血的报道易感性，生发基质在发病机制上重要的形态学特征应在妊娠晚期出现，并在足月时迅速变化。在这项对正常恒河猴胎儿生发基质及其脉管系统的研究中寻找了这些特征。在妊娠晚期，基质细胞、神经胶质细胞、室管膜和毛细血管未显示重要的结构变化。到148天时，终末静脉分支显著增粗，但此时其壁内的细胞和胶原支持极少。后者的特征在妊娠末期才发育形成。这些发现不支持生发基质结构不成熟或特殊化易导致生发基质出血的观点。因此，我们的结果支持最近在生发基质出血的发病机制和预防中对生理参数的重视。
