Wogelius Pia, Poulsen Sven, Sørensen Henrik Toft
Department of Community Oral Health and Pediatric Dentistry, Dental School, Faculty of Health Sciences, University of Aarhus, Denmark.
Community Dent Health. 2004 Sep;21(3):207-11.
To estimate the risk of dental caries in 5-7 year old Danish children who received prescriptions for asthma-drugs.
Population-based cohort-study based on data from a prescription registry and dental database. Setting The County of North Jutland, Denmark.
4,920 children born in 1993, and followed to the end of 2000. Main outcome measures Dental caries in primary canines and molars, and permanent teeth.
Between the age 3 and 5 years 30.4% of the children received one or more prescriptions for asthma-drugs compared to 18.8% between 5 and 7 years of age. Children often received two or more drugs in combination. Approximately 6% of the children received both inhaled cortico-steroids and inhaled beta2-agonists between 3 and 7 years of age. No increased risk of caries could be shown in the primary teeth, while the relative risk of caries in the permanent teeth was estimated at 1.45 (95% C.I.: 0.99-2.11) in children who received prescriptions of both inhaled beta2-agonists and corticosteroids between 5 and 7 years. Of the 169 children who received prescriptions of both inhaled beta2-agonists and cortico-steroids between the ages of 3 and 7 years, the relative risk was estimated at 1.62 (95% C.I.: 1.03-2.56).
Asthma-drugs may increase the risk of caries in newly erupted permanent molars.
评估接受哮喘药物处方的5至7岁丹麦儿童患龋齿的风险。
基于处方登记和牙科数据库数据的人群队列研究。地点：丹麦北日德兰郡。
1993年出生并随访至2000年底的4920名儿童。主要观察指标：乳牙和恒牙中的龋齿情况。
3至5岁儿童中有30.4%接受了一种或多种哮喘药物处方，而5至7岁儿童中这一比例为18.8%。儿童常同时接受两种或更多药物治疗。3至7岁儿童中约6%同时接受吸入性皮质类固醇和吸入性β2激动剂治疗。乳牙龋齿风险未见增加，而5至7岁接受吸入性β2激动剂和皮质类固醇处方的儿童恒牙龋齿相对风险估计为1.45（95%可信区间：0.99 - 2.11）。在3至7岁接受吸入性β2激动剂和皮质类固醇处方的169名儿童中，相对风险估计为1.62（95%可信区间：1.03 - 2.56）。
哮喘药物可能会增加新萌出恒牙患龋齿的风险。
