Bascones Antonio, Gamonal Jorge, Gomez Maria, Silva Augusto, Gonzalez Miguel Angel
Oral Medicine and Periodontology, Department of Stomatology, School of Dentistry, University Complutense of Madrid, Madrid, Spain.
Quintessence Int. 2004 Oct;35(9):706-16.
The aim of this study was to evaluate the relationship between the accumulation of interleukins IL-1beta, TNF-alpha, IL-8, and chemokine RANTES (Regulated upon Activation Normal T-cell Expressed and Secreted) in gingival fluid and periodontal support tissues in patients with periodontitis. A review is also provided of apoptotic processes as events of major importance, highlighting the presence of TUNEL cells and ultrastructural morphologic changes associated with cell apoptosis. There appears to be further evidence to support the important role of inflammation control. Cytokines may be considered as markers of the progression and severity of periodontitis as well as indicators of an appropiate response to treatment. However, further studies are needed to support and characterize this concept.
本研究的目的是评估牙周炎患者龈沟液和牙周支持组织中白细胞介素IL-1β、TNF-α、IL-8以及趋化因子RANTES（活化正常T细胞表达和分泌调节因子）的蓄积之间的关系。还综述了作为重要事件的凋亡过程，强调了TUNEL细胞的存在以及与细胞凋亡相关的超微结构形态学变化。似乎有更多证据支持炎症控制的重要作用。细胞因子可被视为牙周炎进展和严重程度的标志物以及对治疗适当反应的指标。然而，需要进一步的研究来支持和阐述这一概念。
