Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Italy.
BMC Complement Altern Med. 2010 Nov 23;10:73. doi: 10.1186/1472-6882-10-73.
Hypericum perforatum is a medicinal plant species containing many polyphenolic compounds, namely flavonoids and phenolic acids. In this study we evaluate the effect of Hypericum perforatum in animal model of periodontitis.
Periodontitis was induced in adult male Sprague-Dawley rats by placing a nylon thread ligature around the lower 1st molars. Hypericum perforatum was administered at the dose of 2 mg/kg os, daily for eight days. At day 8, the gingivomucosal tissue encircling the mandibular first molar was removed.
Periodontitis in rats resulted in an inflammatory process characterized by edema, neutrophil infiltration and cytokine production that was followed by the recruitment of other inflammatory cells, production of a range of inflammatory mediators such as NF-κB and iNOS expression, the nitration of tyrosine residues and activation of the nuclear enzyme poly (ADP-ribose) polymerase; apoptosis and the degree of gingivomucosal tissues injury. We report here that Hypericum perforatum exerts potent anti-inflammatory effects significantly reducing all of the parameters of inflammation as described above.
Taken together, our results clearly demonstrate that treatment with Hypericum reduces the development of inflammation and tissue injury, events associated with periodontitis.
贯叶金丝桃是一种药用植物，含有许多多酚化合物，即类黄酮和酚酸。在这项研究中，我们评估了贯叶金丝桃在牙周炎动物模型中的作用。
通过在下颌第一磨牙周围放置尼龙线结扎来诱导成年雄性 Sprague-Dawley 大鼠的牙周炎。贯叶金丝桃以 2mg/kg 体重的剂量经口给予，每天一次，共 8 天。在第 8 天，取下环绕下颌第一磨牙的牙龈黏膜组织。
大鼠的牙周炎导致了炎症过程，其特征为水肿、中性粒细胞浸润和细胞因子产生，随后招募了其他炎症细胞，产生了一系列炎症介质，如 NF-κB 和 iNOS 的表达、酪氨酸残基的硝化和核酶多聚（ADP-核糖）聚合酶的激活；细胞凋亡和牙龈黏膜组织损伤的程度。我们在这里报告贯叶金丝桃具有强大的抗炎作用，可显著降低上述所有炎症参数。
综上所述，我们的研究结果清楚地表明，贯叶金丝桃的治疗可减轻与牙周炎相关的炎症和组织损伤的发展。
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