Economides D L, Ferguson J, Mackenzie I Z, Darley J, Ware I I, Holmes-Siedle M
Nuffield Department of Obstetrics and Gynaecology, Churchill Hospital, Headington, Oxford.
Br J Obstet Gynaecol. 1992 Jan;99(1):23-5. doi: 10.1111/j.1471-0528.1992.tb14386.x.
To investigate maternal and fetal folate and vitamin B12 concentrations in pregnancies affected by neural tube defects (NTD).
Measurement of folate and vitamin B12 concentrations in amniotic fluid, fetal blood and maternal blood samples in midgestation.
32 women undergoing termination of pregnancy at 14-21 weeks gestation for social reasons (n = 24) or for fetuses with neural tube defects (n = 8).
Fetoscopy before intra-amniotic injection of prostaglandins.
In normal pregnancies there was a positive correlation between maternal and fetal serum folate, and the fetal serum and red blood cell folate concentrations were higher than the maternal. There were no differences in amniotic fluid, maternal blood or fetal blood folate concentrations between pregnancies with NTD and normal pregnancies. Although amniotic fluid vitamin B12 was lower in pregnancies with NTD, maternal serum vitamin B12 concentration was not reduced.
In this small group of pregnancies with NTD at mid-gestation there is no evidence to suggest folate or vitamin B12 deficiency.
研究神经管缺陷（NTD）妊娠中母体和胎儿的叶酸及维生素B12浓度。
在妊娠中期测量羊水、胎儿血液和母体血液样本中的叶酸和维生素B12浓度。
32名因社会原因（n = 24）或胎儿患有神经管缺陷（n = 8）而在妊娠14 - 21周终止妊娠的女性。
在羊膜腔内注射前列腺素前进行胎儿镜检查。
在正常妊娠中，母体和胎儿血清叶酸之间呈正相关，且胎儿血清和红细胞叶酸浓度高于母体。NTD妊娠与正常妊娠之间的羊水、母体血液或胎儿血液叶酸浓度无差异。虽然NTD妊娠中羊水维生素B12较低，但母体血清维生素B12浓度未降低。
在这一小群妊娠中期患有NTD的孕妇中，没有证据表明存在叶酸或维生素B12缺乏。
