Thorand B, Pietrzik K, Prinz-Langenohl R, Hages M, Holzgreve W
Department of Pathophysiology of Human Nutrition, University of Bonn, Germany.
Z Geburtshilfe Neonatol. 1996 Sep-Oct;200(5):176-80.
In the present study maternal and fetal serum and red cell folate and vitamin B12 concentrations were determined in NTD affected and in control pregnancies. Fetal serum folate (p < 0.001) and red cell folate (p < 0.001) concentrations were significantly higher than maternal levels in the cases as well as in the controls. Maternal and fetal vitamin B12 concentrations did not differ significantly in both groups. There were also no significant differences in maternal and fetal vitamin concentrations in the peripheral blood between cases and controls. However, when a subgroup analysis was performed according to the type of NTD we found significant differences in fetal vitamin B12 status between anencephaly and spina bifida cases as well as between anencephaly cases and the controls.
在本研究中，测定了神经管缺陷（NTD）受累妊娠和对照妊娠中母体和胎儿血清及红细胞叶酸和维生素B12浓度。在病例组和对照组中，胎儿血清叶酸（p<0.001）和红细胞叶酸（p<0.001）浓度均显著高于母体水平。两组中母体和胎儿维生素B12浓度无显著差异。病例组和对照组外周血中母体和胎儿维生素浓度也无显著差异。然而，当根据神经管缺陷类型进行亚组分析时，我们发现无脑儿与脊柱裂病例之间以及无脑儿病例与对照组之间胎儿维生素B12状态存在显著差异。
