乳腺叶状肿瘤和纤维腺瘤的细胞遗传学研究结果。

Cytogenetic findings in phyllodes tumor and fibroadenomas of the breast.

作者信息

Barbosa Miriam L, Ribeiro Enilze M S F, Silva Guaracira F, Maciel Marcos E, Lima Rubens S, Cavalli Luciane R, Cavalli Iglenir J

机构信息

Departamento de Genética, Universidade Federal do Paraná, Centro Politécnico, Jardim das Américas, Curitiba, Paraná, Brazil, 80.000.

出版信息

Cancer Genet Cytogenet. 2004 Oct 15;154(2):156-9. doi: 10.1016/j.cancergencyto.2004.02.005.

DOI:10.1016/j.cancergencyto.2004.02.005

PMID:15474152

Abstract

The cytogenetic data on fibroadenomas and cystosarcoma phyllodes tumor of the breast, which are both biphasic breast tumors composed of epithelial and stromal components, are quite limited. In this study, we report on clonal chromosomal alterations in three fibroadenomas and one cystosarcoma phyllodes analyzed by GTG banding. The fibroadenomas presented mostly numerical abnormalities involving chromosomes 16, 18, and 21. One case presented a deletion on 17p. The cystosarcoma phyllodes presented numerous numerical abnormalities, mostly chromosome gains, and several marker chromosomes.

摘要

乳腺纤维腺瘤和叶状囊肉瘤均为具有上皮和间质成分的双相性乳腺肿瘤，关于它们的细胞遗传学数据非常有限。在本研究中，我们报告了通过GTG显带分析的3例纤维腺瘤和1例叶状囊肉瘤中的克隆性染色体改变。纤维腺瘤大多表现为涉及16号、18号和21号染色体的数目异常。1例出现17p缺失。叶状囊肉瘤表现出大量数目异常，大多为染色体增加，还有几条标记染色体。