整合素在肿瘤血管生成中的作用。
The role of integrins in tumor angiogenesis.
作者信息
Hwang Rosa, Varner Judy
机构信息
Department of Surgery, University of California San Diego, Moores Comprehensive Cancer Center, 9500 Gilman Drive, La Jolla, CA 92093-0987, USA.
出版信息
Hematol Oncol Clin North Am. 2004 Oct;18(5):991-1006, vii. doi: 10.1016/j.hoc.2004.09.010.
Integrins are cell adhesion molecules that play an important role in the regulation of angiogenesis. In this overview, the vascular integrins and their mechanisms of action are outlined. Integrins have been evaluated in preclinical and clinical studies for the treatment of cancer and as diagnostic markers of angiogenesis. Furthermore, integrins are the basis for targeted therapy for solid tumors and novel imaging techniques to assess the angiogenic response of tumors.
整合素是细胞黏附分子，在血管生成调节中发挥重要作用。本综述概述了血管整合素及其作用机制。整合素已在临床前和临床研究中进行评估，用于癌症治疗及作为血管生成的诊断标志物。此外，整合素是实体瘤靶向治疗及评估肿瘤血管生成反应的新型成像技术的基础。
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