Törnqvist M, Svartengren M, Ericsson C H
Department of Radiobiology, Stockholm University, Sweden.
Chem Biol Interact. 1992 Mar;82(1):91-8. doi: 10.1016/0009-2797(92)90016-e.
Dose monitoring of exogenous methylators by measurement of N-methylvaline in hemoglobin (Hb) is rendered difficult due to a relatively high, variable background in unexposed persons. A kinetic study indicates intracellular S-adenosylmethionine to be a main source of these background methylations. A comparison of twin pairs indicates that the variation in methylvaline levels is partly hereditary (P less than 0.001). Therefore, in a study of monozygotic twin pairs discordant for tobacco smoking the resolving power of the monitoring was increased and in vivo doses of methylators from the smoke could be more easily monitored through their adducts to Hb. Probably, twin studies offer a useful tool for the identification and quantification of electrophiles of endogenous and exogenous origin.
由于未接触者体内背景值相对较高且存在变化，通过测量血红蛋白（Hb）中的N - 甲基缬氨酸来监测外源性甲基化剂的剂量变得困难。一项动力学研究表明，细胞内S - 腺苷甲硫氨酸是这些背景甲基化的主要来源。对双胞胎的比较表明，甲基缬氨酸水平的变化部分是可遗传的（P小于0.001）。因此，在一项针对吸烟情况不一致的同卵双胞胎研究中，监测的分辨能力得到了提高，并且通过其与Hb的加合物可以更轻松地监测来自烟雾的甲基化剂的体内剂量。双胞胎研究可能为识别和量化内源性和外源性亲电试剂提供了一个有用的工具。
