Trosic Ivancica, Busljeta Ivana, Pavicic Ivan
Department of Radiology, Institute for Medical Research and Occupational Health, Ksaverska cesta 2, HR-10000 Zagreb, Croatia.
Toxicol Lett. 2004 Dec 1;154(1-2):125-32. doi: 10.1016/j.toxlet.2004.07.011.
The influence of 2.45 GHz microwave (RF/MW) irradiation on blood-forming cells after whole-body irradiation of rats was investigated. The exposures were conducted with a field power density of 5-10 mW/cm2, and whole-body average specific absorption rate (SAR) of 1-2 W/kg. Four experimental subgroups were created and irradiated 2, 8, 15 or 30 days, for 2 h a day, 7 days a week. Concurrent sham-exposed rats were also included in the study. The cell response was assessed by number and type of the bone marrow nuclear cells and peripheral blood white cells using standard laboratory methods. Significant decrease in lymphoblast count was obtained at 15 and 30th experimental day (P < 0.05), whereas other examined parameters did not significantly differed in comparison to the sham-exposed controls. The findings point out at stress response in blood-forming system in rats after selected microwave exposure, which could be considered rather as sign of adaptation than malfunction.
研究了2.45 GHz微波(射频/微波)辐照对大鼠全身辐照后造血细胞的影响。辐照时场功率密度为5-10 mW/cm2,全身平均比吸收率(SAR)为1-2 W/kg。设立四个实验亚组,分别在辐照后2、8、15或30天进行辐照,每天2小时,每周7天。同时,研究中还纳入了假辐照的大鼠。使用标准实验室方法,通过骨髓核细胞和外周血白细胞的数量及类型评估细胞反应。在实验的第15天和第30天,成淋巴细胞计数显著下降(P < 0.05),而与假辐照对照组相比,其他检测参数无显著差异。研究结果指出,在选定的微波辐照后,大鼠造血系统会出现应激反应,这更可被视为一种适应迹象而非功能故障。