Cinaz P, Karakasü D S, Camurdan M O, Bideci A, Ayvali E D, Yücel C
Department of Pediatric Endocrinology, Gazi University, Ankara, Turkey.
Biol Trace Elem Res. 2004 Sep;100(3):185-93. doi: 10.1385/bter:100:3:185.
This study was planned to investigate goiter prevalence and serum selenium and urine iodine status among school-age children in the Ankara region of Turkey. Nine hundred five (905) children were investigated; 847 of them were included in the study. Thyroid ultrasound was performed on children who were suspected of being goitrous at physical examination. Serum TSH, thyroxine, triiodotyronine, thyroid antibody, and urine iodine concentrations (UIC) are also measured. Ultrasound measurements revealed a goiter in 107 (12.6%) of the 847 children. Goiter prevalence was significantly lower among iodized-salt users compared to the noniodized salt using group. UIC and serum selenium levels in the goitrous group were significantly lower compared to the nongoitrous group. Despite legally enforced table salt iodization, the region shows the characteristics of mild iodine deficiency. In addition to lower UIC, goitrous children have lower serum selenium levels compared to the nongoitrous ones. Thus, selenium deficiency plays an important role in goiter endemics in Turkey. It can be postulated that table salt iodization might not be enough for the preventive measures of goiter, but informing people about the correct ways of iodized salt consumption, enforcing the iodization of industrial salts, and, as important as these measures, taking selenium deficiency into consideration are essential for preventing goiters in endemic areas.
本研究旨在调查土耳其安卡拉地区学龄儿童的甲状腺肿患病率以及血清硒和尿碘状况。共对905名儿童进行了调查，其中847名儿童被纳入研究。对体检时疑似患有甲状腺肿的儿童进行了甲状腺超声检查。还测量了血清促甲状腺激素、甲状腺素、三碘甲状腺原氨酸、甲状腺抗体以及尿碘浓度（UIC）。超声检查发现，847名儿童中有107名（12.6%）患有甲状腺肿。与未使用碘盐的组相比，使用碘盐的人群中甲状腺肿患病率显著较低。甲状腺肿组的UIC和血清硒水平显著低于非甲状腺肿组。尽管法律强制规定食盐加碘，但该地区仍表现出轻度碘缺乏的特征。除了UIC较低外，甲状腺肿儿童的血清硒水平也低于非甲状腺肿儿童。因此，硒缺乏在土耳其甲状腺肿地方病中起着重要作用。可以推测，食盐加碘可能不足以预防甲状腺肿，但是告知人们碘盐的正确食用方法、强制工业盐加碘以及与这些措施同样重要的是，考虑硒缺乏对于预防地方病地区的甲状腺肿至关重要。
