Gashu D, Stoecker B J, Adish A, Haki G D, Bougma K, Aboud F E, Marquis G S
Center for Food Science and Nutrition, Addis Ababa University, Addis Ababa, Ethiopia.
Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK, USA.
Eur J Clin Nutr. 2016 Aug;70(8):929-34. doi: 10.1038/ejcn.2016.27. Epub 2016 Mar 16.
BACKGROUND/OBJECTIVES: Selenium (Se) as part of glutathione peroxidase and iodothyronine deiodinase enzymes influences thyroid metabolism. This study investigated the association of serum Se levels with thyroid metabolism of severely iodine-deficient young children from the Amhara region of Ethiopia.
SUBJECTS/METHODS: In a cross-sectional study, Se, thyroid-stimulating hormone, total thyroxin, total triiodothyronine and thyroglobulin in serum of children (N=628) 54-60 months of age from the Amhara region, Ethiopia, were analyzed. In addition, iodine in urine and household salt was analyzed, and the presence of goiter was assessed.
The median serum Se concentration was 61.4 μg/l (10.7-290.9 μg/l). Selenium deficiency (serum Se <70 μg/l) was detected in 57.8% (N=349) of the children. The median urinary iodine concentration (UIC) was 9.8 μg/l. The majority (86.6%, N=449) of children had UIC below the recommended value (100 μg/l). In addition, 59.8% (N=310) of children were severely iodine deficient (UIC<20 μg/l). Only 12.7% of salt samples had iodine. Goiter was present in 44.6% (N=280) of the children. Selenium-deficient children had higher serum thyroxin (T4) than children with normal serum Se concentration (P<0.001).
Serum Se was negatively associated with T4 level in young children from the Amhara region of Ethiopia and may endanger the effectiveness of the salt iodization program.
背景/目的：作为谷胱甘肽过氧化物酶和碘甲状腺原氨酸脱碘酶的组成部分，硒（Se）会影响甲状腺代谢。本研究调查了埃塞俄比亚阿姆哈拉地区严重缺碘幼儿的血清硒水平与甲状腺代谢之间的关联。
对象/方法：在一项横断面研究中，对埃塞俄比亚阿姆哈拉地区54至60月龄儿童（N = 628）血清中的硒、促甲状腺激素、总甲状腺素、总三碘甲状腺原氨酸和甲状腺球蛋白进行了分析。此外，还分析了尿碘和家庭食盐中的碘，并评估了甲状腺肿的情况。
血清硒浓度中位数为61.4μg/l（10.7 - 290.9μg/l）。57.8%（N = 349）的儿童检测出硒缺乏（血清硒<70μg/l）。尿碘浓度（UIC）中位数为9.8μg/l。大多数儿童（86.6%，N = 449）的UIC低于推荐值（100μg/l）。此外，59.8%（N = 310）的儿童严重缺碘（UIC<20μg/l）。只有12.7%的盐样含碘。44.6%（N = 280）的儿童有甲状腺肿。硒缺乏儿童的血清甲状腺素（T4）高于血清硒浓度正常的儿童（P<0.001）。
埃塞俄比亚阿姆哈拉地区幼儿的血清硒与T4水平呈负相关，可能会危及食盐加碘计划的有效性。
