Lichtenstein Gary R, Hanauer Stephen B, Kane Sunanda V, Present Daniel H
University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Inflamm Bowel Dis. 2004 Jul;10 Suppl 2:S2-10. doi: 10.1097/00054725-200407002-00002.
Crohn's disease is an idiopathic, chronic inflammatory disorder of the digestive tract with heterogeneous clinical presentations. Crohn's is currently not a curable disease, and patients are faced with a lifetime of recurrent disease flare-ups and remissions. Management strategies for Crohn's must therefore be targeted toward lifelong management, taking into consideration not only the short-term but also the long-term aspects of the disease. With this in mind, here we review the classifications and natural history of Crohn's disease and discuss possible predictive factors for the disease evolution in a patient. Here we also evaluate the current preferable treatment practices, based on scientifically valid research and collective clinical experience, for the management of mild to moderate Crohn's disease.
克罗恩病是一种特发性慢性消化道炎症性疾病，临床表现多样。目前克罗恩病无法治愈，患者面临疾病反复发作和缓解的一生。因此，克罗恩病的管理策略必须针对终身管理，不仅要考虑疾病的短期情况，还要考虑长期情况。考虑到这一点，我们在此回顾克罗恩病的分类和自然史，并讨论患者疾病进展的可能预测因素。我们还根据科学有效的研究和集体临床经验，评估目前治疗轻至中度克罗恩病的优选治疗方法。
