Krantz Jody S, Mack Wendy J, Hodis Howard N, Liu Chao-Ran, Liu Ci-Hua, Kaufman Francine R
Children's Hospital of Orange County, Orange, California, USA.
J Pediatr. 2004 Oct;145(4):452-7. doi: 10.1016/j.jpeds.2004.06.042.
To evaluate the degree of atherosclerosis and its risk factors in adolescents and young adults with type 1 diabetes.
We measured carotid artery intima-media thickness (IMT) in 142 subjects with type 1 diabetes (mean [SD] age = 16.0 [2.6] years) and 87 control subjects (18.8 [3.1] years). Fasting lipid and homocysteine levels, degree of glycemic control, blood pressure, and body mass index were measured in persons with diabetes.
The mean carotid IMT was greater in persons with diabetes ( P = .002). Among subjects with type 1 diabetes, lipid levels were significantly higher in female subjects compared with male subjects. The mean carotid IMT was significantly higher in persons with a diabetic complication (including hypertension, retinopathy, or microalbuminuria). In male subjects but not female subjects, HDL cholesterol and the LDL/HDL ratio were correlated with carotid IMT.
Adolescents with type 1 diabetes have increased atherosclerosis compared with control subjects. Risk factors for increased carotid IMT in these younger patients include diabetic complications and HDL cholesterol and the LDL/HDL ratio, which may be sex-specific.
评估1型糖尿病青少年及青年人群的动脉粥样硬化程度及其危险因素。
我们测量了142例1型糖尿病患者（平均[标准差]年龄 = 16.0 [2.6]岁）和87例对照者（18.8 [3.1]岁）的颈动脉内膜中层厚度（IMT）。对糖尿病患者测量了空腹血脂和同型半胱氨酸水平、血糖控制程度、血压及体重指数。
糖尿病患者的平均颈动脉IMT更大（P = .002）。在1型糖尿病患者中，女性患者的血脂水平显著高于男性患者。有糖尿病并发症（包括高血压、视网膜病变或微量白蛋白尿）的患者，其平均颈动脉IMT显著更高。在男性患者而非女性患者中，高密度脂蛋白胆固醇及低密度脂蛋白/高密度脂蛋白比值与颈动脉IMT相关。
与对照者相比，1型糖尿病青少年的动脉粥样硬化有所增加。这些较年轻患者颈动脉IMT增加的危险因素包括糖尿病并发症、高密度脂蛋白胆固醇及低密度脂蛋白/高密度脂蛋白比值，这些因素可能具有性别特异性。
