Vriens Joris, Owsianik Grzegorz, Voets Thomas, Droogmans Guy, Nilius Bernd
Department of Physiology, Campus Gasthuisberg, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
Pflugers Arch. 2004 Dec;449(3):213-26. doi: 10.1007/s00424-004-1314-1.
Transient receptor potential (TRP) channels constitute a large and diverse family of channel proteins that are expressed in many tissues and cell types in both vertebrates and invertebrates. While the biophysical features of many of the mammalian TRP channels have been described, relatively little is known about their biological roles. Invertebrate TRPs offer valuable genetic handles for characterizing the functions of these cation channels in vivo. Importantly, studies in model organisms can help to identify fundamental mechanisms involved in normal cellular functions and human disease. In this review, we give an overview of the different TRP channels known in the two most utilized invertebrate models, the nematode Caenorhabditis elegans and the fruit-fly Drosophila melanogaster, and discuss briefly the heuristic impact of these invertebrate channels with respect to TRP function in mammals.
瞬时受体电位（TRP）通道构成了一个庞大且多样的通道蛋白家族，在脊椎动物和无脊椎动物的许多组织和细胞类型中均有表达。虽然许多哺乳动物TRP通道的生物物理特性已被描述，但对其生物学作用却知之甚少。无脊椎动物的TRP通道为在体内表征这些阳离子通道的功能提供了有价值的遗传学手段。重要的是，对模式生物的研究有助于识别正常细胞功能和人类疾病所涉及的基本机制。在本综述中，我们概述了两种最常用的无脊椎动物模型——线虫秀丽隐杆线虫和果蝇黑腹果蝇中已知的不同TRP通道，并简要讨论了这些无脊椎动物通道对哺乳动物TRP功能的启发作用。
