Gao Song, Kaudimba Keneilwe Kenny, Guo Shanshan, Zhang Shuang, Liu Tiemin, Chen Peijie, Wang Ru
School of Kinesiology, Shanghai University of Sport, Shanghai, China.
Institute of Sport Science, Harbin Sport University, Harbin, China.
Front Physiol. 2020 Jul 30;11:836. doi: 10.3389/fphys.2020.00836. eCollection 2020.
Cardiovascular disease is one of the chronic conditions with the highest mortality rate in the world. Underlying conditions such as hypertension, metabolic disorders, and habits like smoking are contributors to the manifestation of cardiovascular diseases. The treatment of cardiovascular diseases is inseparable from the development of drugs. Consequently, this has led to many researchers to focus on the search for effective drug targets. The transient receptor potential channel Ankyrin 1 (TRPA1) subtype is a non-selective cation channel, which belongs to the transient receptor potential (TRP) ion channel. Previous studies have shown that members of the TRP family contribute significantly to cardiovascular disease. However, many researchers have not explored the role of TRPA1 as a potential target for the treatment of cardiovascular diseases. Furthermore, recent studies revealed that TRPA1 is commonly expressed in the vascular endothelium. The endothelium is linked to the causes of some cardiovascular diseases, such as atherosclerosis, myocardial fibrosis, heart failure, and arrhythmia. The activation of TRPA1 has a positive effect on atherosclerosis, but it has a negative effect on other cardiovascular diseases such as myocardial fibrosis and heart failure. This review introduces the structural and functional characteristics of TRPA1 and its importance on vascular physiology and common cardiovascular diseases. Moreover, this review summarizes some evidence that TRPA1 is correlated to cardiovascular disease risk factors.
心血管疾病是世界上死亡率最高的慢性疾病之一。诸如高血压、代谢紊乱等潜在病症以及吸烟等习惯都是心血管疾病表现的促成因素。心血管疾病的治疗离不开药物的研发。因此，这使得许多研究人员专注于寻找有效的药物靶点。瞬时受体电位锚蛋白1（TRPA1）亚型是一种非选择性阳离子通道，属于瞬时受体电位（TRP）离子通道。先前的研究表明，TRP家族成员对心血管疾病有显著影响。然而，许多研究人员尚未探究TRPA1作为心血管疾病治疗潜在靶点的作用。此外，最近的研究表明，TRPA1在血管内皮中普遍表达。内皮与某些心血管疾病的病因有关，如动脉粥样硬化、心肌纤维化、心力衰竭和心律失常。TRPA1的激活对动脉粥样硬化有积极作用，但对其他心血管疾病如心肌纤维化和心力衰竭有消极作用。这篇综述介绍了TRPA1的结构和功能特征及其对血管生理学和常见心血管疾病的重要性。此外，这篇综述总结了一些TRPA1与心血管疾病风险因素相关的证据。
