Valbuena Gustavo, Walker David H
Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77555-0609, USA.
Virchows Arch. 2005 Jan;446(1):21-7. doi: 10.1007/s00428-004-1120-3. Epub 2004 Oct 5.
Fractalkine (CX3CL1) is a chemokine expressed mainly by endothelial cells, which are the major cellular targets of rickettsiae. We used immunohistochemistry to investigate the normal expression of CX3CL1 in mice and the kinetics of expression of this chemokine throughout the course of lethal and sublethal rickettsial infections in a mouse model of spotted-fever group rickettsioses. The peak of expression of fractalkine on day 3 of infection coincided with the time of infiltration of macrophages into infected tissues and preceded the peak of rickettsial content in tissues.
趋化因子（CX3CL1）是一种主要由内皮细胞表达的趋化因子，而内皮细胞是立克次体的主要细胞靶点。我们运用免疫组织化学方法研究了CX3CL1在小鼠体内的正常表达情况，以及在斑点热群立克次体病小鼠模型中，该趋化因子在致死性和亚致死性立克次体感染全过程中的表达动力学。感染第3天趋化因子表达高峰与巨噬细胞浸润感染组织的时间一致，且早于组织中立克次体含量的高峰。
