Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, The University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77555-0609, USA.
Thromb Haemost. 2009 Dec;102(6):1071-9. doi: 10.1160/TH09-03-0186.
The vascular endothelium is the main target of a limited number of infectious agents, Rickettsia, Ehrlichia ruminantium, and Orientia tsutsugamushi are among them. These arthropod-transmitted obligately-intracellular bacteria cause serious systemic diseases that are not infrequently lethal. In this review, we discuss the bacterial biology, vector biology, and clinical aspects of these conditions with particular emphasis on the interactions of these bacteria with the vascular endothelium and how it responds to intracellular infection. The study of these bacteria in relevant in vivo models is likely to offer new insights into the physiology of the endothelium that have not been revealed by other models.
血管内皮细胞是少数几种传染性病原体的主要靶标，其中包括立克次体、牛埃立克体和恙虫病东方体。这些节肢动物传播的专性细胞内细菌会导致严重的全身性疾病，且并非罕见致命。在这篇综述中，我们讨论了这些疾病的细菌生物学、媒介生物学和临床方面，特别强调了这些细菌与血管内皮细胞的相互作用以及内皮细胞对细胞内感染的反应。在相关的体内模型中研究这些细菌，可能会提供一些尚未通过其他模型揭示的关于内皮细胞生理学的新见解。
