Henkel K-O, Gerber Th, Dietrich W, Bienengräber V
Klinik für Mund-, Kiefer- und plastische Gesichtschirurgie, Medizinische Fakultät, Universität Rostock.
Mund Kiefer Gesichtschir. 2004 Sep;8(5):277-81. doi: 10.1007/s10006-004-0561-9. Epub 2004 Jul 28.
Up to now hydroxyapatite (HA) and beta-tricalciumphosphate (beta-TCP) ceramics have been routinely sintered at temperatures between 1100 degrees and 1500 degrees C. Our new calcium ceramic is fabricated by a sol-gel process at 200 degrees C. The aim of this investigation was to test the biodegradation of and the induction of bone formation by this material.
Eighteen 1-year-old Goettingen minipigs were divided into three groups. Critical size defects (>5 cm(3)) in the mandible were treated differently in all three animals (group 1: filling with 40% beta-TCP plus 60% HA, group 2: pure HA was applied, group 3 served as controls: only gelatinous material was given). Macroscopic and microscopic investigations of the former defects were made 8 months postoperatively. RESULTS. In groups 1 and 2 biodegradation of more than 93% of the new calcium phosphate formula was found 8 months postoperatively and considered to be very good. No difference was observed between pure HA (group 2) and the combination of HA and beta-TCP (group 1). In both groups complete bone formation was seen macroscopically in the former defects. In the control group only incomplete bone formation with 48.4% of the defect area was noted. This difference was significant ( p<0.001).
The new calcium phosphate formula made by a sol-gel method at 120 degrees C seems to be suitable for filling bone defects and is of interest for orthopedic surgery, traumatology, craniomaxillofacial surgery, and dentistry.
迄今为止，羟基磷灰石（HA）和β-磷酸三钙（β-TCP）陶瓷通常在1100摄氏度至1500摄氏度之间的温度下烧结。我们的新型钙陶瓷是通过溶胶-凝胶工艺在200摄氏度下制备的。本研究的目的是测试这种材料的生物降解性和骨形成诱导能力。
将18只1岁的哥廷根小型猪分为三组。对所有三只动物的下颌骨临界尺寸缺损（>5立方厘米）进行不同处理（第1组：填充40%β-TCP加60%HA，第2组：应用纯HA，第3组作为对照组：仅给予凝胶状材料）。术后8个月对先前的缺损进行宏观和微观研究。结果。术后8个月，在第1组和第2组中发现新磷酸钙配方的生物降解率超过93%，被认为非常好。纯HA（第2组）和HA与β-TCP的组合（第1组）之间未观察到差异。在两组中，先前缺损处宏观上均可见完全骨形成。在对照组中，仅观察到不完全骨形成，缺损面积为48.4%。这种差异具有统计学意义（p<0.001）。
通过溶胶-凝胶法在120摄氏度下制备的新型磷酸钙配方似乎适用于填充骨缺损，在骨科手术、创伤学、颅颌面外科和牙科领域具有应用价值。
