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永久性心脏起搏作为神经心源性(反射性)晕厥的主要治疗方法。

Permanent cardiac pacing as primary therapy for neurocardiogenic (reflex) syncope.

作者信息

Kosinski Daniel J, Grubb Blair P, Wolfe Douglas A

机构信息

Electrophysiology Section, Division of Cardiology, Dept. of Medicine, Medical College of Ohio, Toledo, OH 43614, USA.

出版信息

Clin Auton Res. 2004 Oct;14 Suppl 1:76-9. doi: 10.1007/s10286-004-1011-3.

DOI:10.1007/s10286-004-1011-3
PMID:15480934
Abstract

Recurrent reflex (or neurocardiogenic) syncope is a common clinical problem. Pacemaker therapy has been advocated as a potential therapy in severe or drug refractory cases of reflex syncope, while others have suggested that it may provide a benefit if employed as a primary therapeutic modality. The following paper reviews the concepts behind pacemaker therapy for reflex syncope and the results of various clinical trials that have evaluated its potential utility as a primary therapeutic modality.

摘要

复发性反射性(或神经心源性)晕厥是一个常见的临床问题。起搏器治疗已被提倡作为严重或药物难治性反射性晕厥病例的一种潜在治疗方法,而其他人则认为,如果将其作为主要治疗方式使用,可能会带来益处。以下论文回顾了反射性晕厥起搏器治疗背后的概念以及评估其作为主要治疗方式潜在效用的各种临床试验结果。

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Permanent cardiac pacing as primary therapy for neurocardiogenic (reflex) syncope.永久性心脏起搏作为神经心源性(反射性)晕厥的主要治疗方法。
Clin Auton Res. 2004 Oct;14 Suppl 1:76-9. doi: 10.1007/s10286-004-1011-3.
2
[Permanent cardiac pacing in vasovagal syncope: when and which?].
Arch Cardiol Mex. 2006 Apr-Jun;76 Suppl 2:S225-8.
3
The expectation effect and cardiac pacing for refractory vasovagal syncope.难治性血管迷走性晕厥的期望效应与心脏起搏
Am J Med. 2007 Jan;120(1):54-62. doi: 10.1016/j.amjmed.2006.05.046.
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Reflex vasovagal syncope--is there a benefit in pacemaker therapy?反射性血管迷走性晕厥——起搏器治疗有获益吗?
Rev Port Cardiol. 2014 May;33(5):297-303. doi: 10.1016/j.repc.2014.02.007. Epub 2014 Jun 2.
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Pacing Clin Electrophysiol. 2017 Nov;40(11):1302-1307. doi: 10.1111/pace.13194. Epub 2017 Oct 6.
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A randomized, double-blind, placebo-controlled study of permanent cardiac pacing for the treatment of recurrent tilt-induced vasovagal syncope. The vasovagal syncope and pacing trial (SYNPACE).一项关于永久性心脏起搏治疗复发性倾斜诱发血管迷走性晕厥的随机、双盲、安慰剂对照研究。血管迷走性晕厥与起搏试验(SYNPACE)。
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J Arrhythm. 2018 Aug 3;34(5):556-564. doi: 10.1002/joa3.12102. eCollection 2018 Oct.
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Renal nerve stimulation for treatment of neurocardiogenic syncope: a review from perspective of commercialization potential.肾神经刺激治疗神经心源性晕厥:从商业化潜力角度的综述
Ir J Med Sci. 2018 Feb;187(1):45-54. doi: 10.1007/s11845-017-1643-7. Epub 2017 Jun 14.
3
Preliminary observations on the use of closed-loop cardiac pacing in patients with refractory neurocardiogenic syncope.

本文引用的文献

1
Pacemaker therapy for prevention of syncope in patients with recurrent severe vasovagal syncope: Second Vasovagal Pacemaker Study (VPS II): a randomized trial.起搏器治疗预防复发性严重血管迷走性晕厥患者晕厥:第二项血管迷走性起搏器研究(VPS II):一项随机试验。
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难治性神经心源性晕厥患者使用闭环心脏起搏的初步观察
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Pathophysiology of syncope.晕厥的病理生理学
Clin Auton Res. 2004 Oct;14 Suppl 1:18-24. doi: 10.1007/s10286-004-1004-2.
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Circulation. 2001 Jul 3;104(1):52-7. doi: 10.1161/hc2601.091708.
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Dual-chamber pacing in the treatment of neurally mediated tilt-positive cardioinhibitory syncope : pacemaker versus no therapy: a multicenter randomized study. The Vasovagal Syncope International Study (VASIS) Investigators.双腔起搏治疗神经介导的倾斜试验阳性心脏抑制型晕厥:起搏器治疗与非治疗对照:一项多中心随机研究。血管迷走性晕厥国际研究(VASIS)调查组
Circulation. 2000 Jul 18;102(3):294-9. doi: 10.1161/01.cir.102.3.294.
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Pathophysiology and differential diagnosis of neurocardiogenic syncope.神经心源性晕厥的病理生理学与鉴别诊断
Am J Cardiol. 1999 Oct 21;84(8A):3Q-9Q. doi: 10.1016/s0002-9149(99)00691-8.
6
Dual chamber pacing for neurally mediated syncope with a prominent cardioinhibitory component.双腔起搏用于治疗具有显著心脏抑制成分的神经介导性晕厥。
Pacing Clin Electrophysiol. 1999 Jul;22(7):999-1003. doi: 10.1111/j.1540-8159.1999.tb00563.x.
7
The North American Vasovagal Pacemaker Study (VPS). A randomized trial of permanent cardiac pacing for the prevention of vasovagal syncope.北美血管迷走性起搏器研究(VPS)。一项关于永久性心脏起搏预防血管迷走性晕厥的随机试验。
J Am Coll Cardiol. 1999 Jan;33(1):16-20. doi: 10.1016/s0735-1097(98)00549-x.
8
DDD pacing with rate drop response function versus DDI with rate hysteresis pacing for cardioinhibitory vasovagal syncope.具有心率下降反应功能的双腔按需起搏(DDD)与具有心率滞后起搏功能的双腔抑制型起搏(DDI)用于心脏抑制型血管迷走性晕厥的比较
Pacing Clin Electrophysiol. 1998 Nov;21(11 Pt 2):2178-81. doi: 10.1111/j.1540-8159.1998.tb01148.x.
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Effect of dual-chamber pacing with automatic rate-drop sensing on recurrent neurally mediated syncope.具有自动心率下降感知功能的双腔起搏对复发性神经介导性晕厥的影响。
Am J Cardiol. 1998 Jan 15;81(2):158-62. doi: 10.1016/s0002-9149(97)00891-6.
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Clinical experience with Thera DR rate-drop response pacing algorithm in carotid sinus syndrome and vasovagal syncope. The International Rate-Drop Investigators Group.Thera DR 心率下降反应起搏算法在颈动脉窦综合征和血管迷走性晕厥中的临床经验。国际心率下降研究组。
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