Maestracci P, Grimaud D, Livrelli N, Griffon H
Ann Anesthesiol Fr. 1976;17(11):1255-9.
In this work, the authors are studying the cardio-vascular effects of nicergoline. To do so, the drug is made to compete with metaraminol whose dominant alphamimetic effects are known. This experimentation was performed in 7 patients in coma stage III or IV and whose vascular receptors were active. Those 7 patients were submitted continuous metaraminol perfusion and a steady state vasoconstriction was thus obtained. A single intravenous injection of 10 mg nicergoline resulted in vasodilation with a fall in vascular resistance and a moderate fall in mean blood pressure. Cardiac output remained unchanged. This work confirme thus the alphasympatholytic effects of nicergoline.
在这项研究中，作者正在研究尼麦角林对心血管的影响。为此，使该药物与间羟胺竞争，间羟胺主要的α拟交感神经效应是已知的。该实验在7名处于III期或IV期昏迷且血管受体活跃的患者中进行。这7名患者接受了间羟胺的持续灌注，从而获得了稳定状态的血管收缩。单次静脉注射10毫克尼麦角林导致血管舒张，血管阻力下降，平均血压适度下降。心输出量保持不变。因此，这项研究证实了尼麦角林的α交感神经阻滞作用。
