Samardzić R, Beleslin D
C R Seances Soc Biol Fil. 1982;176(4):488-93.
Nicergoline, injected into the cerebral ventricles of anaesthetized cats induced a moderate, but longlasting and dose-dependent fall of the blood pressure. Dihydroergotamine, in moderate doses, had no effect on the arterial blood pressure. Toxic doses of nicergoline and dihydroergotamine provoked a pronounced fall of the arterial blood pressure and inhibition of the respiration. Bradycardia only appeared after toxic doses of dihydroergotamine. It is concluded that the hypotensive effect of nicergoline is at least in part central in origin.
将尼麦角林注入麻醉猫的脑室可引起血压适度但持久且剂量依赖性的下降。中等剂量的双氢麦角胺对动脉血压无影响。尼麦角林和双氢麦角胺的中毒剂量可引起动脉血压显著下降并抑制呼吸。心动过缓仅在双氢麦角胺中毒剂量后出现。结论是，尼麦角林的降压作用至少部分源于中枢。
