Liu Jenn-Hwa, Tsai Huey-Ling, Hsu Soa-Ming, Hu Dong-Her, Chen Shy-Shen
Division of Gastroenterology, Shalu Kuang-Tien Hospital, Taichung, Taiwan.
Kaohsiung J Med Sci. 2004 Feb;20(2):78-82. doi: 10.1016/S1607-551X(09)70088-9.
Clear cell hepatocellular carcinoma (HCC) is an uncommon variant of HCC. It is considered to have a better prognosis than non-clear cell HCC, but recent large studies show that there is some controversy. DNA image cytometry reveals diploid and non-diploid DNA content tumors that have different pleomorphisms and mitosis corresponding to different prognoses. Clear cell HCC is classified as focal or diffuse. Herein, we report a rare case of a 61-year-old male with two adjacent hyper- and hypoechoic hepatic nodules and an alpha-fetoprotein concentration of 6,370 ng/mL. Pathologic examination of a specimen obtained during wedge hepatectomy showed both clear cell and non-clear cell HCC. Bone metastasis was later found. We suggest that a patient with clear cell HCC should be followed up closely after complete resection.
透明细胞肝细胞癌(HCC)是HCC的一种不常见变体。它被认为比非透明细胞HCC预后更好,但最近的大型研究表明存在一些争议。DNA图像细胞术揭示了具有不同多形性和有丝分裂的二倍体和非二倍体DNA含量肿瘤,这与不同的预后相对应。透明细胞HCC分为局灶性或弥漫性。在此,我们报告一例罕见病例,一名61岁男性,有两个相邻的高回声和低回声肝结节,甲胎蛋白浓度为6370 ng/mL。楔形肝切除术中获取的标本病理检查显示同时存在透明细胞和非透明细胞HCC。后来发现有骨转移。我们建议透明细胞HCC患者在完全切除后应密切随访。