Cocco L, Capitani S, Maraldi N M, Martelli A M, Mazzotti G, Manzoli F A
Cellular Signalling Laboratory, Department of Anatomical Sciences, University of Bologna, Bologna, Italy.
J Endocrinol Invest. 2004;27(6 Suppl):143-5.
The existence of a nuclear polyphosphoinositol metabolism independent from that at the plasma membrane is now widely recognized. Specific changes in the nuclear phosphatidylinositol (Ptdlns) metabolism have been implicated in cell growth, differentiation, and neoplastic transformation. Here we shall review the main features of nuclear inositol lipid signaling through type I IGF receptor, focusing the attention on the role of inositide-specific phospholipase C (PI-PLC) beta1 in cell proliferation and differentiation, given its peculiar localization in the nuclear compartment.
现在人们普遍认识到存在一种独立于质膜的核多磷酸肌醇代谢。核磷脂酰肌醇（Ptdlns）代谢的特定变化与细胞生长、分化和肿瘤转化有关。在这里，我们将综述通过I型胰岛素样生长因子受体的核肌醇脂质信号传导的主要特征，鉴于其在核区室中的特殊定位，重点关注肌醇特异性磷脂酶C（PI-PLC）β1在细胞增殖和分化中的作用。
