通过1型胰岛素样生长因子受体的核磷脂酶C信号传导及其在细胞生长和分化中的作用。

Nuclear phospholipase C signaling through type 1 IGF receptor and its involvement in cell growth and differentiation.

作者信息

Faenza Irene, Billi Anna Maria, Follo Matilde Yung, Fiume Roberta, Martelli Alberto Maria, Cocco Lucio, Manzoli Lucia

机构信息

Cellular Signalling Laboratory, Department of Anatomical Sciences, University of Bologna, Italy.

出版信息

Anticancer Res. 2005 May-Jun;25(3B):2039-41.

PMID:16158942

Abstract

The existence of a nuclear polyphosphoinositol metabolism, independent from that at the plasma cell membrane, is now widely recognized. Specific changes in the nuclear phosphatidylinositol (PtdIns) metabolism have been implicated in cell growth, differentiation and neoplastic transformation. Here, the main features of nuclear inositol lipid signaling through type I IGF receptor, is reviewed with particular attention to the role of inositide-specific phospholipase C (PI-PLC) beta1 in cell proliferation and differentiation, due to the peculiar localization of this molecule in the nuclear compartment.

摘要

一种独立于浆细胞膜的核多磷酸肌醇代谢的存在，如今已得到广泛认可。核磷脂酰肌醇（PtdIns）代谢的特定变化与细胞生长、分化及肿瘤转化有关。在此，我们综述了通过I型胰岛素样生长因子受体进行的核肌醇脂质信号传导的主要特征，特别关注肌醇特异性磷脂酶C（PI-PLC）β1在细胞增殖和分化中的作用，这是由于该分子在核区室中的特殊定位。